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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Unraveling glutamate-opioid receptor interactions using high-resolution electron microscopy: Implications for addiction-related processes
Experimental neurology, v 229(2), pp 207-213
01 Jun 2011
PMID: 21459090
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis for prominent interactions of glutamate and opioid receptor systems in preclinical models of drug addiction. The review begins by highlighting the advantages of high-resolution electron microscopic immunohistochemistry for unraveling receptor interactions at the synapse. With an emphasis on a recent publication describing the anatomical relationship between the R-opioid receptor (MOR) and the AMPA-GluR2 subunit (Beckerman, M. A., and Glass, M.J., 2011. Ultrastructural relationship between the AMPA-GluR2 receptor subunit and the mu-opioid receptor in the mouse central nucleus of the amygdala. Exp Neurol), we review the anatomical evidence for opioid-induced neural plasticity of glutamate receptors in selected brain circuits that are key integrative substrates in the brain's motivational system. The findings stress the importance of glutamate-opioid interactions as important neural mediators of adaptations to chronic use of abused drugs, particularly within the amygdaloid complex. (C) 2011 Elsevier Inc. All rights reserved.
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Details
- Title
- Unraveling glutamate-opioid receptor interactions using high-resolution electron microscopy: Implications for addiction-related processes
- Creators
- Jillian L. Scavone - Thomas Jefferson UniversityEsther Asan - University of WürzburgElisabeth J. Van Bockstaele - Thomas Jefferson University
- Publication Details
- Experimental neurology, v 229(2), pp 207-213
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R01DA009082 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01 DA009082; R01 DA009082-14 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000291419400004
- Scopus ID
- 2-s2.0-79956161170
- Other Identifier
- 991021903402504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences