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Unsaturated nitriles: Optimized coupling of the chloroprene Grignard reagent with omega-brominitriles
Journal article   Peer reviewed

Unsaturated nitriles: Optimized coupling of the chloroprene Grignard reagent with omega-brominitriles

Fraser F Fleming and Tao Jiang
Journal of organic chemistry, Vol.62(22), p7890
31 Oct 1997

Abstract

Diels-Alder reaction Nitriles Observations
The Diels-alder reaction is a powerful organic synthesis reaction. An effective synthesis of dienes for type II intramolecular Diels-Alder (IMDA) reactions involves coupling electrophiles with 1-methylene-2-propenylmagnesium chloride, or chloroprene Grignard reagent. The coupling of 1-methylene-2-propenylmagnesium chloride with omega-bromonitriles achieved good yields of unsaturated nitriles.

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