Journal article
Unusual Genetic Aberrations Including a Deletion of KLF6 Tumor Suppressor Gene Revealed by Integrated Cytogenetic Approaches in a Pediatric Ewing Sarcoma
Journal of pediatric hematology/oncology, v 37(1), pp E51-E54
01 Jan 2015
PMID: 24322504
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ewing sarcoma is the third most common sarcoma in children and young adults. Its characteristic chromosomal rearrangement results in a chimerical EWSR1-ETS transcription factor. Secondary genetic alterations are very common. Membranous expression of CD99 is seen in almost all tumors. We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6. The latter has not been described previously in pediatric neoplasms. Molecular pathways in tumorigenesis and genetic complexity in cancer are discussed.
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Details
- Title
- Unusual Genetic Aberrations Including a Deletion of KLF6 Tumor Suppressor Gene Revealed by Integrated Cytogenetic Approaches in a Pediatric Ewing Sarcoma
- Creators
- Jason C. White - St. Christopher's Hospital for ChildrenGregory E. Halligan - Drexel UniversityJean-Pierre de Chadarevian - Drexel Univ, Coll Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USAJudy M. Pascasio - Drexel Univ, Coll Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USAHope H. Punnet - Drexel Univ, Coll Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USAJinglan Liu - Drexel Univ, Coll Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
- Publication Details
- Journal of pediatric hematology/oncology, v 37(1), pp E51-E54
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000346633800010
- Scopus ID
- 2-s2.0-84920572417
- Other Identifier
- 991019168646404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Hematology
- Oncology
- Pediatrics