Journal article
Unveiling dynamic enhancer-promoter interactions in Drosophila melanogaster
Biochemical Society transactions, v 50(6), pp 1633-1642
16 Dec 2022
PMID: 36350004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Proper enhancer-promoter interactions are essential to maintaining specific transcriptional patterns and preventing ectopic gene expression. Drosophila is an ideal model organism to study transcriptional regulation due to extensively characterized regulatory regions and the ease of implementing new genetic and molecular techniques for quantitative analysis. The mechanisms of enhancer-promoter interactions have been investigated over a range of length scales. At a DNA level, compositions of both enhancer and promoter sequences affect transcriptional dynamics, including duration, amplitude, and frequency of transcriptional bursting. 3D chromatin topology is also important for proper enhancer-promoter contacts. By working competitively or cooperatively with one another, multiple, simultaneous enhancer-enhancer, enhancer-promoter, and promoter- promoter interactions often occur to maintain appropriate levels of mRNAs. For some long-range enhancer-promoter interactions, extra regulatory elements like insulators and tethering elements are required to promote proper interactions while blocking aberrant ones. This review provides an overview of our current understanding of the mechanism of enhancer-promoter interactions and how perturbations of such interactions affect transcription and subsequent physiological outcomes.
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Details
- Title
- Unveiling dynamic enhancer-promoter interactions in Drosophila melanogaster
- Creators
- Hao Deng - University of PennsylvaniaGaochen Jin - University of PennsylvaniaBomyi Lim - University of Pennsylvania
- Publication Details
- Biochemical Society transactions, v 50(6), pp 1633-1642
- Publisher
- Portland Press Ltd
- Number of pages
- 10
- Grant note
- National Science Foundation CAREER; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000913316600001
- Scopus ID
- 2-s2.0-85144198452
- Other Identifier
- 991022138679204721
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- Web of Science research areas
- Biochemistry & Molecular Biology