Journal article
Updating Evidence for Cationization of Polymers in the Gas Phase during Matrix-Assisted Laser Desorption/Ionization
European journal of mass spectrometry (Chichester, England), v 11(1)
Feb 2005
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Matrix-assisted laser desorption/ionization (MALDI) techniques have been developed to determine the chemical structure of a variety of industrial polymers. Despite the enormous popularity and power of MALDI, the details of the cationization mechanisms of the process are currently rather poorly understood. The MALDI cationization of polymer analytes was investigated previously by Hoberg and co-workers.
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They used layered samples to explore the role of gas-phase cationization in MALDI of polymers. This paper seeks to extend the work initiated by Hoberg and co-workers and update the results of the earlier work. The new experiments take advantage of a MALDI instrument with delayed extraction and show that separation in the initial acceleration region of the mass spectrometer is not a key component of cationization. Investigations of tri-layer samples by time-of-flight secondary ion mass spectrometry (ToF-SIMS) also show that there is considerable interaction among the layers. These interactions, specifically the solubility of the salts in the solvents, account for the presence of the bottom layer cation in the mass spectra. The absence of the top layer cation in the mass spectra is due to the inability of the polymer oligomers to penetrate that layer during desorption.
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Details
- Title
- Updating Evidence for Cationization of Polymers in the Gas Phase during Matrix-Assisted Laser Desorption/Ionization
- Creators
- Scott D. Hanton - Air Products & ChemicalsKevin G. Owens - Drexel UniversityCynthia Chavez-Eng - Drexel UniversityAnne-Mette Hoberg - University of WarwickPeter J. Derrick - University of Warwick
- Publication Details
- European journal of mass spectrometry (Chichester, England), v 11(1)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000229097800003
- Scopus ID
- 2-s2.0-18844389739
- Other Identifier
- 991019169790604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physics, Atomic, Molecular & Chemical
- Spectroscopy