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Journal article
Uptake of Cyclodextrin Nanoparticles by Macrophages is Dependent on Particle Size and Receptor-Mediated Interactions
ACS applied bio materials, v 7(8), pp 4856-4866
17 Jan 2024
PMID: 38231485
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Physiochemical properties of nanoparticles, such as their size and chemical composition, dictate their interaction with professional phagocytes of the innate immune system. Macrophages, in particular, are key regulators of the immune microenvironment that heavily influence particle biodistribution as a result of their uptake. This attribute enables macrophage-targeted delivery, including for phenotypic modulation. Saccharide-based materials, including polyglucose polymers and nanoparticles, are efficient vehicles for macrophage-targeted delivery. Here, we investigate the influence of particle size on cyclodextrin nanoparticle (CDNP) uptake by macrophages and further examine the receptor-mediated interactions that drive macrophage-targeted delivery. We designed and synthesized CDNPs ranging in size from 25 nm to >100 nm in diameter. Increasing particle size was correlated with greater uptake by macrophages
. Both scavenger receptor A1 and mannose receptor were critical mediators of macrophage-targeted delivery, inhibition of which reduced the extent of uptake. Finally, we investigated the cellular bioavailability of drug-loaded CDNPs using a model anti-inflammatory drug, celastrol, which demonstrated that drug bioactivity is improved by CDNP loading relative to free drug alone. This study thus elucidates the interactions between the polyglucose nanoparticles and macrophages, thereby facilitating their application in macrophage-targeted drug delivery that has applications in the context of tissue injury and repair.
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Details
- Title
- Uptake of Cyclodextrin Nanoparticles by Macrophages is Dependent on Particle Size and Receptor-Mediated Interactions
- Creators
- Shreya S Soni - Drexel University, School of Biomedical Engineering, Science, and Health SystemsKenneth M Kim - Drexel University, Microbiology and ImmunologyBiplab Sarkar - Drexel University, School of Biomedical Engineering, Science, and Health SystemsChristopher B Rodell - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- ACS applied bio materials, v 7(8), pp 4856-4866
- Publisher
- American Chemical Society (ACS)
- Number of pages
- 11
- Grant note
- R35 GM147184 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001162313200001
- Scopus ID
- 2-s2.0-85183017340
- Other Identifier
- 991021822907404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology