Journal article
Urban Particulate Matter Air Pollution Is Associated With Subclinical Atherosclerosis Results From the HNR (Heinz Nixdorf Recall) Study
Journal of the American College of Cardiology, v 56(22), pp 1803-1808
23 Nov 2010
PMID: 21087707
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives The aim of this study was to investigate the association of long-term residential exposure to fine particles with carotid intima-media thickness (CIMT).
Background Experimental and epidemiological evidence suggest that long-term exposure to air pollution might have a causal role in atherogenesis, but epidemiological findings are still inconsistent. We investigate whether urban particulate matter (PM) air pollution is associated with CIMT, a marker of subclinical atherosclerosis.
Methods We used baseline data (2000 to 2003) from the HNR (Heinz Nixdorf Recall) study, a population-based cohort of 4,814 participants, 45 to 75 years of age. We assessed residential long-term exposure to PM with a chemistry transport model and measured distance to high traffic. Multiple linear regression was used to estimate associations of air pollutants and traffic with CIMT, adjusting for each other, city of residence, age, sex, diabetes, and lifestyle variables.
Results Median CIMT of the 3,380 analyzed participants was 0.66 mm (interquartile range 0.16 mm). An interdecile range increase in PM2.5 (4.2 mu g/m(3)), PM10 (6.7 mu g/m(3)), and distance to high traffic (1,939 m) was associated with a 4.3% (95% confidence interval [CI]: 1.9% to 6.7%), 1.7% (95% CI: -0.7% to 4.1%), and 1.2% (95% CI: -0.2% to 2.6%) increase in CIMT, respectively.
Conclusions Our study shows a clear association of long-term exposure to PM2.5 with atherosclerosis. This finding strengthens the hypothesized role of PM2.5 as a risk factor for atherogenesis. (J Am Coll Cardiol 2010;56:1803-8) (C) 2010 by the American College of Cardiology Foundation
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Details
- Title
- Urban Particulate Matter Air Pollution Is Associated With Subclinical Atherosclerosis Results From the HNR (Heinz Nixdorf Recall) Study
- Creators
- Marcus Bauer - University of Duisburg-EssenSusanne Moebus - University of Duisburg-EssenStefan Moehlenkamp - University of Duisburg-EssenNico Dragano - Heinrich Heine University DüsseldorfMichael Nonnemacher - University of Duisburg-EssenMiriam Fuchsluger - University of Duisburg-EssenChristoph Kessler - Rhenish Institute for Environmental ResearchHermann Jakobs - Rhenish Institute for Environmental ResearchMichael Memmesheimer - Rhenish Institute for Environmental ResearchRaimund Erbel - University of Duisburg-EssenKarl-Heinz Joeckel - University of Duisburg-EssenBarbara Hoffmann - University of Duisburg-EssenHNR Study Invest Grp
- Publication Details
- Journal of the American College of Cardiology, v 56(22), pp 1803-1808
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- Heinz Nixdorf Foundation Sarstedt AG and Company SI236/10-1; SI236/9-1 / German Research Council (DFG); German Research Foundation (DFG) German Ministry of Education and Science Imatron, Inc., South San Francisco, California VW Foundation; Volkswagen
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000284308400004
- Scopus ID
- 2-s2.0-78449305860
- Other Identifier
- 991020099057404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems