Journal article
Urinary and plasma fluoride levels in pregnant women from Mexico City
Environmental research, v 150, pp 489-495
Oct 2016
PMID: 27423051
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is need to assess the developmental neurotoxicity of fluoride. Our knowledge of prenatal fluoride exposure is challenged as few population-based studies have been conducted and these generally date back several decades, provide incomplete data on sociodemographic variables, and have methodological limitations.
To measure urinary and plasma fluoride levels across three time points in pregnant mothers who were enrolled in the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohort study.
Fluoride levels were characterized in archived urine and plasma from 872 pregnant mothers sampled from the ELEMENT cohort. Various statistical methods were used to analyze the fluoride data with particular consideration for changes across three stages of pregnancy and against sociodemographic variables.
All samples had detectable levels of fluoride. The mean urinary and plasma fluoride levels were 0.91 and 0.0221mg/L respectively, and these were not statistically different across three stages of pregnancy. Fluoride levels correlated across the stages of pregnancy studied, with stronger correlations between neighboring stages. Urinary fluoride changed as pregnancy progressed with levels increasing until ~23 weeks and then decreasing until the end of pregnancy. For plasma fluoride, there was a decreasing trend but this was not of statistical significance. Creatinine-adjusted urinary fluoride levels did not associate consistently with any of the sociodemographic variables studied.
This study provides the most extensive characterization to date of fluoride exposure throughout pregnancy. These results provide the foundation to explore exposure-related health outcomes in the ELEMENT cohort and other studies.
•There is growing concern that fluoride may be a neurodevelopmental toxicant.•We characterize urine and plasma fluoride levels in 872 pregnant mothers.•Fluoride levels through pregnancy were relatively stable.
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Details
- Title
- Urinary and plasma fluoride levels in pregnant women from Mexico City
- Creators
- Deena B. Thomas - University of MichiganNiladri Basu - McGill UniversityE. Angeles Martinez-Mier - Indiana University – Purdue University IndianapolisBrisa N. Sánchez - University of MichiganZhenzhen Zhang - University of MichiganYun Liu - University of MichiganRajendra Prasad Parajuli - McGill UniversityKaren Peterson - University of MichiganAdriana Mercado-Garcia - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, MéxicoMorteza Bashash - University of TorontoMauricio Hernández-Avila - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, MéxicoHoward Hu - University of TorontoMartha Maria Téllez-Rojo - Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, México
- Publication Details
- Environmental research, v 150, pp 489-495
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000382903100059
- Scopus ID
- 2-s2.0-84978209194
- Other Identifier
- 991020099739704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health