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Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study
Journal article   Peer reviewed

Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study

Marissa Hauptman, Medina S. Jackson-Browne, Stefanie Busgang, Syam S. Andra, Marisa A. Patti, Noelle B. Henderson, Paul Curtin, Susan L. Teitelbaum, Keith Acosta, Michelle Maciag, …
International journal of hygiene and environmental health, v 262, 114430
01 Sep 2024
DOI: https://doi.org/10.1016/j.ijheh.2024.114430
PMID: 39205349
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://pmc.ncbi.nlm.nih.gov/articles/PMC11972426/pdf/nihms-2064154.pdfView
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Abstract

Chemical mixtures Childhood asthma School Urinary biomarkers
The burden of pediatric asthma and other allergic diseases is not evenly distributed among United States populations. To determine whether urinary biomarkers are associated with asthma morbidity, and if associations vary by child race, ethnicity and sex. This study includes n = 152 children with physician-diagnosed asthma who participated in the School Inner-City Asthma Intervention Study (SICAS-2). Metabolites of phenol, paraben, polycyclic aromatic hydrocarbons, and phthalate analytes were analyzed from urine samples collected at baseline. Asthma symptom days over the past 2 weeks were dichotomized to no asthma symptom days or any asthma symptom days. Cross-sectional regression models were adjusted for age, sex, number of colds, household income, prescription control, race and ethnicity, body mass index (BMI) percentile, and smoke exposure. Weighted quantile sum regression was used to analyze each chemical class and a total mixture effect, controlling for the same covariates. Analyses were conducted with the assistance of the National Institute of Environmental Health Sciences Children's Health Exposure Analysis Resource (CHEAR). Participants were mostly Hispanic/Latino and low income with an average age of 7.83 years and the average maximum asthma symptom days over the past two weeks of 2.13 (standard deviation: 3.56). The maximum concentrations indicate extreme values for several chemicals, including bisphenol-3, 2,5-dichlorophenol, propyl and methyl parabens, triclosan, methyl paraben and cotinine. We found a significant interaction effect and differing contributions of analytes for children with allergen sensitivity versus those that did not. For stratified analyses assessing effect modification by child race and ethnicity, weighted quantile sum interaction models showed reduced odds of asthma symptoms to a greater magnitude in children of other races and ethnicities compared to Black, Non-Hispanic children. Preliminary analyses of the association between environmental chemical exposure and asthma symptoms among inner-city children revealed an inverse association, which may be due to personal care and medication use and can be understood further in future analyses. Beneficial effects were detected for most of the chemicals.

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#6 Clean Water and Sanitation
#3 Good Health and Well-Being

InCites Highlights

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Collaboration types
Domestic collaboration
Web of Science research areas
Infectious Diseases
Public, Environmental & Occupational Health
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