Journal article
Urinary cadmium concentration and the risk of ischemic stroke
Neurology, v 91(4), pp e382-E391
24 Jul 2018
PMID: 29934425
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine the association between urinary cadmium levels and the incidence of ischemic stroke and to explore possible effect modifications.
A case-cohort study was designed nested in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, including 680 adjudicated incident cases of ischemic stroke and 2,540 participants in a randomly selected subcohort. Urinary creatinine-corrected cadmium concentration was measured at baseline. Multivariable-adjusted hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated with the Barlow weighting method for the Cox proportional hazards regression model.
The median urinary cadmium concentration was 0.42 (interquartile range 0.27-0.68) μg/g creatinine. After adjustment for potential confounders, urinary cadmium was associated with increased incidence of ischemic stroke (quintile 5 vs quintile 1: HR 1.50, 95% CI 1.01-2.22,
for trend = 0.02). The observed association was more pronounced among participants in the lowest serum zinc tertile (tertile 3 vs tertile 1: HR 1.82, 95% CI 1.06-3.11,
for trend = 0.004,
for interaction = 0.05) but was attenuated and became nonsignificant among never smokers (tertile 3 vs tertile 1: never smokers: HR 1.27, 95% CI 0.80-2.03,
for trend = 0.29; ever smokers: HR 1.60, 95% CI 1.06-2.43,
for trend = 0.07,
for interaction = 0.51).
Findings from this study suggest that cadmium exposure may be an independent risk factor for ischemic stroke in the US general population. Never smoking and maintaining a high serum zinc level may ameliorate the potential adverse effects of cadmium exposure.
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Details
- Title
- Urinary cadmium concentration and the risk of ischemic stroke
- Creators
- Cheng Chen - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillPengcheng Xun - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillCari Tsinovoi - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillLeslie A McClure - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillJohn Brockman - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillLeslie MacDonald - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillMary Cushman - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillJianwen Cai - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillLisa Kamendulis - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillJason Mackey - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel HillKa He - From the Departments of Epidemiology and Biostatistics (C.C., P.X., C.T., K.H.) and Environmental Health (L.K.), School of Public Health, and Department of Neurology (J.M.), School of Medicine, Indiana University, Bloomington; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; Columbia Research Reactor (J.B.), University of Missouri; National Institute for Occupational Safety and Health (L.M.), Centers for Disease Control and Prevention, Washington, DC; Department of Medicine (M.C.), Larner College of Medicine, University of Vermont, Burlington; and Department of Biostatistics (J.C.), University of North Carolina at Chapel Hill. kahe@indiana.edu
- Publication Details
- Neurology, v 91(4), pp e382-E391
- Publisher
- United States
- Grant note
- R01 ES021735 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000440909200010
- Scopus ID
- 2-s2.0-85070483094
- Other Identifier
- 991014878300904721
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- Clinical Neurology