Journal article
Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS)
World journal of urology, v 38(2), pp 433-446
Feb 2020
PMID: 31028455
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To correlate the presence of fungi with symptom flares, pain and urinary severity in a prospective, longitudinal study of women with IC/BPS enrolled in the MAPP Research Network.
Flare status, pelvic pain, urinary severity, and midstream urine were collected at baseline, 6 and 12 months from female IC/BPS participants with at least one flare and age-matched participants with no reported flares. Multilocus PCR coupled with electrospray ionization/mass spectrometry was used for identification of fungal species and genus. Associations between "mycobiome" (species/genus presence, relative abundance, Shannon's/Chao1 diversity indices) and current flare status, pain, urinary severity were evaluated using generalized linear mixed models, permutational multivariate analysis of variance, Wilcoxon's rank-sum test.
The most specific analysis detected 13 fungal species from 8 genera in 504 urine samples from 202 females. A more sensitive analysis detected 43 genera. No overall differences were observed in fungal species/genus composition or diversity by flare status or pain severity. Longitudinal analyses suggested greater fungal diversity (Chao1 Mean Ratio 3.8, 95% CI 1.3-11.2, p = 0.02) and a significantly greater likelihood of detecting any fungal species (OR = 5.26, 95% CI 1.1-25.8, p = 0.04) in high vs low urinary severity participants. Individual taxa analysis showed a trend toward increased presence and relative abundance of Candida (OR = 6.63, 95% CI 0.8-58.5, p = 0.088) and Malassezia (only identified in 'high' urinary severity phenotype) for high vs low urinary symptoms.
This analysis suggests the possibility that greater urinary symptom severity is associated with the urinary mycobiome urine in some females with IC/BPS.
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Details
- Title
- Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS)
- Creators
- J Curtis Nickel - Kingston General HospitalAlisa Stephens - University of PennsylvaniaJ Richard Landis - University of PennsylvaniaChris Mullins - National Institutes of HealthAdrie van Bokhoven - University of Colorado DenverJennifer T Anger - Cedars-Sinai Medical CenterA Lenore Ackerman - Cedars-Sinai Medical CenterJayoung Kim - Cedars-Sinai Medical CenterSiobhan Sutcliffe - Washington University in St. LouisJaroslaw E Krol - Department of Microbiology and Immunology, Drexel College of Medicine, Philadelphia, PA, USABhaswati Sen - Drexel UniversityJocelyn Hammond - Drexel UniversityGarth D Ehrlich - Drexel UniversityMultidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
- Publication Details
- World journal of urology, v 38(2), pp 433-446
- Publisher
- Springer Nature
- Grant note
- U01 DK103260 / NIDDK NIH HHS U01DK082316 / NIDDK NIH HHS U01 DK082315 / NIDDK NIH HHS R56 DK117261 / NIDDK NIH HHS U01DK103260 / NIDDK NIH HHS U01 DK082325 / NIDDK NIH HHS U01DK082315 / NIDDK NIH HHS U01 DK103271 / NIDDK NIH HHS U01DK082333 / NIDDK NIH HHS U01 DK082333 / NIDDK NIH HHS U24 DK082316 / NIDDK NIH HHS U01DK103271 / NIDDK NIH HHS U01 DK082316 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000511513400023
- Scopus ID
- 2-s2.0-85065011416
- Other Identifier
- 991019168673904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Urology & Nephrology