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Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Urine-Based Liquid Biopsy for Nonurological Cancers
Genetic testing and molecular biomarkers, v 23(4), pp 277-283
Apr 2019
PMID: 30986103
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The use of circulating cell-free DNA for detection of cancer genetics has been studied extensively. Liquid biopsy often refers to the use of blood as a minimally invasive source of body fluid for detecting circulating tumor DNA (ctDNA). However, urine collection, which is completely noninvasive, has been shown to also have great promise to serve as an alternate body fluid source for ctDNA. In this review article, we focus on the clinical utility of urine for genetic liquid biopsy of nonurological cancers.
Although still in early stages as compared with blood-based liquid biopsy, recent studies have demonstrated the value of urine-based liquid biopsies for: nonurological cancer screening; early detection; monitoring for recurrence and metastasis; and therapeutic efficacy. Overall, the completely noninvasive and patient-friendly nature of the urine-based biopsy warrants further development and offers a promising alternative to blood-based biopsies.
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Details
- Title
- Urine-Based Liquid Biopsy for Nonurological Cancers
- Creators
- Surbhi Jain - JBS Science (United States)Selena Y Lin - JBS Science (United States)Wei Song - JBS Science (United States)Ying-Hsiu Su - Baruch S. Blumberg Institute
- Publication Details
- Genetic testing and molecular biomarkers, v 23(4), pp 277-283
- Publisher
- Mary Ann Liebert
- Grant note
- R44 CA165312 / NCI NIH HHS R01 CA202769 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000464574800011
- Scopus ID
- 2-s2.0-85064431773
- Other Identifier
- 991021463578604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Genetics & Heredity