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Journal article
Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients
Cholesterol, v 2012
25 Jul 2012
PMID: 22888414
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
. In clinical practice, most coronary artery disease patients are not achieving their recommend LDL-cholesterol goal of <70 mg/dL. Methods. We conducted a retrospective analysis of outpatient electronic health records and the most recent lipid profile, lipid-lowering medications and doses were collected. Results. We identified 9950 coronary artery disease patients. Only 37% on a statin alone achieved an LDL-cholesterol of <70 mg/dL, and most were on moderate-to-high-potency statins. The intensity of statin therapy did not improve LDL-cholesterol goal attainment. Among patients on combination therapy, 41% on statin plus ezetimibe and 46% on statin plus niacin achieved an LDL-cholesterol of <70 mg/dL ( and <0.0001 versus statin alone). If patients were switched to a high-potency statin LDL-cholesterol goal attainment of <70 mg/dL would increase to 46% and would increase up to 72% with combination therapy. Conclusions. Most coronary artery disease patients in clinical practice do not attain an LDL-cholesterol of <70 mg/dL, even among patients on high potency statins. The combination of statin plus either ezetimibe or niacin is the most effective regimen to achieve an LDL-cholesterol of <70 mg/dL, however, these drug combinations are used infrequently in clinical practice.
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Details
- Title
- Use of Lipid-Lowering Medications and the Likelihood of Achieving Optimal LDL-Cholesterol Goals in Coronary Artery Disease Patients
- Creators
- Dean G. Karalis - Cardiology Consultants of Philadelphia, Philadelphia, PA 19107, USA.Brett Victor - Drexel UniversityLilian Ahedor - Drexel UniversityLongjian Liu - Drexel University
- Publication Details
- Cholesterol, v 2012
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000215112900018
- Scopus ID
- 2-s2.0-84864915536
- Other Identifier
- 991019169658804721
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- Web of Science research areas
- Endocrinology & Metabolism