Journal article
Use of a Motor Load Analyzer to Monitor the Granulation Process in a High Intensity Mixer
Drug development and industrial pharmacy, v 13(3), pp 405-435
1987
Abstract
Abstract
A motor load analyzer instrumented to a high intensity mixer was examined for its ability to monitor the granulation process with varying formulation and processing parameters. A lactose/microcrystalline cellulose blend with povidone as the binder was used as the test system.
The motor load analyzer was able to note chopper operation and liquid addition methods. However, it could not differentiate between povidone addition as an aqueous solution or as part of the lactose microcrystalline cellulose blend, followed by massing with water. The compression characteristics of the granulations depended upon chopper usage, and povidone and liquid amounts, and their methods of addition.
Metrics
Details
- Title
- Use of a Motor Load Analyzer to Monitor the Granulation Process in a High Intensity Mixer
- Creators
- R. J. Timko - Wilmington UniversityJ. S. Barrett - Wilmington UniversityP. A. Mchugh - Wilmington UniversityS. T. Chen - Wilmington UniversityH. A. Rosenberg - Wilmington University
- Publication Details
- Drug development and industrial pharmacy, v 13(3), pp 405-435
- Publisher
- Informa UK Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:A1987G990000002
- Scopus ID
- 2-s2.0-0023185344
- Other Identifier
- 991019173675304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy