Journal article
Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs
Journal of rehabilitation research and development, Vol.41(3A), pp.373-382
01 May 2004
PMID: 15543453
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important for understanding speech. Objective tests must be reliable, sensitive to hearing change, and time efficient. Auditory brainstem responses (ABRs) appear well suited to this task; however, current ABR techniques have limitations. Conventional clicks stimulate middle (1-4 kHz) rather than high frequencies (>8 kHz). Responses to HF tone bursts require considerable recording time. We hypothesized that using HF band-limited clicks (HF clicks) could overcome these limitations. Two different HF clicks, with bandwidths of 8-14 kHz were used to elicit ABRs. The current study compared responses among these stimuli. The results demonstrate the reliability of HF-click responses and of tone bursts presented in trains.
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Details
- Title
- Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs
- Creators
- Curtin R Mitchell - National Center for Rehabilitative Auditory Research (R&D-NCRAR), Portland, OR 97207, USARoger M Ellingson - National Rehabilitation CenterJames A HenryStephen A Fausti - National Rehabilitation Center
- Publication Details
- Journal of rehabilitation research and development, Vol.41(3A), pp.373-382
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Audiology - Distance
- Web of Science ID
- WOS:000224246800025
- Scopus ID
- 2-s2.0-3542995652
- Other Identifier
- 991022057791304721
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- Web of Science research areas
- Rehabilitation