Journal article
Use of serum soluble interleukin-2 receptor levels to monitor the progression of cutaneous T-cell lymphoma
Journal of the American Academy of Dermatology, v 38(2)
1998
PMID: 9486676
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Abstract
Background: The serum concentration of soluble a chain of the interleukin-2 receptor (sIL-2R) correlates with tumor burden in cutaneous T-cell lymphoma (CTCL). Therefore the sIL-2R level may be useful to monitor the condition of patients treated with extracorporeal photopheresis or other treatments.
Objective: Our goal was to determine the utility of serum sIL-2R as a test in monitoring of patients with advanced CTCL.
Methods: Serum sIL-2R was measured serially in 36 patients with advanced CTCL treated with extracorporeal photopheresis and other modalities (interferon alfa, methotrexate, topical nitrogen mustard, electron beam).
Results: Serum concentrations of sIL-2R as well as lactate dehydrogenase (LDH) correlated strongly with lymph node size, but only sIL-2R correlated significantly with the severity of skin manifestations in erythrodermic patients. In addition, serum sIL-2R, but not LDH, was significantly higher in patients with nodal involvement. The level of sIL-2R also was significantly higher in patients with large-cell transformation in the skin or lymph nodes compared with patients without transformed disease. During treatment, serum concentrations of both serum sIL-2R and LDH correlated with changes in clinical status, but only sIL-2R showed statistically significant differences in mean levels for different relative global response scores. Pretreatment levels of both sIL-2R and LDH correlated significantly with survival, but only sIL-2R retained significance when both were entered into the Cox proportionate hazards model.
Conclusion: The concentration of serum sIL-2R correlates well with disease status and is more useful than LDH or Sézary cell counts to monitor clinical change in patients with advanced CTCL. Moreover, our data suggest that sIL-2R is produced at a relatively low rate by tissue-based lymphoma cells, and that large-cell transformation in CTCL results in marked increase in sIL-2R production in some patients. (J Am Acad Dermatol 1998;38:207-20.)
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Details
- Title
- Use of serum soluble interleukin-2 receptor levels to monitor the progression of cutaneous T-cell lymphoma
- Creators
- Eric C. Vonderheid - Allegheny University of the Health SciencesQian Zhang - Allegheny University of the Health SciencesStuart R. Lessin - Allegheny University of the Health SciencesMarcia Polansky - Allegheny University of the Health SciencesJ.Todd Abrams - Allegheny University of the Health SciencesRobert D. Bigler - Allegheny University of the Health SciencesMariusz A. Wasik - Allegheny University of the Health Sciences
- Publication Details
- Journal of the American Academy of Dermatology, v 38(2)
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000072043700007
- Scopus ID
- 2-s2.0-0031885856
- Other Identifier
- 991019168366704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology