Journal article
Use of the DrexelMed HIV/AIDS cohort to identify viral markers predictive of disease progression and neuroAIDS
Journal of neurovirology, Vol.13, pp.80-80
01 Jan 2007
Abstract
The long terminal repeat (LTR) regulates human immunodeficiency virus type 1 (HIV-1) viral gene expression via interactions with multiple viral and host transcriptional control factors. Previous studies have examined sequence variation at CCAAT enhancer binding protein (C/EBP) sites I and II, and Sp sites I, II, and III in peripheral blood (PB)-derived LTRs from HIV-1-infected patients representing increasing degrees of disease severity. The 3T configuration of C/EBP site I (C-to-T change at position 3) and 5T configuration of Sp site III (C-to-T change at position 5) were variants found in low frequencies in PB-derived LTRs derived from patients at early stages of HIV-1 disease, and at relatively high frequencies in patients in late stage disease. Sequence variation at these sites was also examined in LTRs derived from various brain compartments of patients with and without HIV-associated dementia. The 3T C/EBP site I and 5T Sp site III were identified in brain-derived LTRs from patients diagnosed with HIVD, but was absent in patients without dementia. To assess whether these or other correlative or predictive viral markers could be identified in a larger patient population in the era of highly active antiretroviral therapy (HAART), HIV-1-positive patients from the Drexel University College of Medicine HIV/AIDS Clinic have been enrolled in a longitudinal study to examine the change in prevalence of specific viral genetic markers. Herein, an initial analysis of the DrexelMed HIV/AIDS cohort for the presence of specific configurations of HIV-1 LTR transcription factor binding sites is presented.
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Details
- Title
- Use of the DrexelMed HIV/AIDS cohort to identify viral markers predictive of disease progression and neuroAIDS
- Creators
- K FlaigB IrishE KilareskiJ JacobsonM NonnemacherB Wigdahl
- Publication Details
- Journal of neurovirology, Vol.13, pp.80-80
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170156904721