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Journal article
Use of transcranial low-intensity focused ultrasound for targeted delivery of stem cell-derived exosomes to the brain
Scientific reports, v 13(1), pp 17707-17707
18 Oct 2023
PMID: 37853206
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The blood–brain barrier (BBB) presents a significant challenge for targeted drug delivery. A proposed method to improve drug delivery across the BBB is focused ultrasound (fUS), which delivers ultrasound waves to a targeted location in the brain and is hypothesized to open the BBB. Furthermore, stem cell-derived exosomes have been suggested as a possible anti-inflammatory molecule that may have neural benefits, if able to pass the BBB. In the present study, transcranial low-intensity focused ultrasound (LIFU), without the use of intravenous microbubbles, was assessed for both (1) its ability to influence the BBB, as well as (2) its ability to increase the localization of intravenously administered small molecules to a specific region in the brain. In vivo rat studies were conducted with a rodent-customized 2 MHz LIFU probe (peak pressure = 1.5 MPa), and injection of labeled stem cell-derived exosomes. The results suggested that LIFU (without microbubbles) did not appear to open the BBB after exposure times of 20, 40, or 60 min; instead, there appeared to be an increase in transcytosis of the dextran tracer. Furthermore, the imaging results of the exosome study showed an increase in exosome localization in the right hippocampus following 60 min of targeted LIFU.
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Details
- Title
- Use of transcranial low-intensity focused ultrasound for targeted delivery of stem cell-derived exosomes to the brain
- Creators
- J. Haroon - The Regenesis Project, Santa Monica, CA USAK. Aboody - City of HopeL. Flores - City of HopeM. McDonald - Duarte, CA USAK. Mahdavi - The Regenesis Project, Santa Monica, CA USAM. Zielinski - The Regenesis Project, Santa Monica, CA USAK. Jordan - The Regenesis Project, Santa Monica, CA USAE. Rindner - The Regenesis Project, Santa Monica, CA USAJ. Surya - The Regenesis Project, Santa Monica, CA USAV. Venkatraman - The Regenesis Project, Santa Monica, CA USAV. Go-Stevens - City of HopeG. Ngai - City of HopeJ. Lara - City of HopeC. Hyde - City of HopeS. Schafer - Drexel UniversityM. Schafer - Drexel UniversityA. Bystritsky - University of California, Los AngelesI. Nardi - Kimera Labs Inc., Miramar, USAT. Kuhn - Neurobehavioral SystemsD. Ross - Kimera Labs Inc., Miramar, USAS. Jordan - University of California, Los Angeles
- Publication Details
- Scientific reports, v 13(1), pp 17707-17707
- Publisher
- Nature Publishing Group UK
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001094254900052
- Scopus ID
- 2-s2.0-85174456018
- Other Identifier
- 991021480072604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences