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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series
SAGE open medical case reports, v 10, p2050313
Jan 2022
PMID: 35693924
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Treatment of neonates with persistent pulmonary hypertension of newborn includes optimization of ventilatory support, use of pulmonary vasodilators, and/or inotropic support. If refractory to this management, some may require extracorporeal membrane oxygenation. We describe a case series of 10 neonates with refractory persistent pulmonary hypertension of newborn treated with vasopressin in a single tertiary center. Mean initiation time of vasopressin was at 30 h of life with a dose ranging from 10 to 85 milliunits/kg/h. Oxygenation index decreased after 12 h of vasopressin exposure (25 to 11) and mean arterial pressure improved after 1 h (45 to 58 mm Hg). Extracorporeal membrane oxygenation was averted in 50% of the cases with transient hyponatremia as the only notable side effect. Although our findings are exploratory and further research is needed to establish safety and efficacy, our experience suggests that vasopressin may have rescue properties in the management of refractory persistent pulmonary hypertension of newborn.
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Details
- Title
- Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series
- Creators
- Swosti Joshi - St. Christopher's Hospital for ChildrenVilmaris Quinones Cardona - Drexel UniversityOgechukwu R Menkiti - St. Christopher's Hospital for Children
- Publication Details
- SAGE open medical case reports, v 10, p2050313
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000811565600001
- Scopus ID
- 2-s2.0-85131378756
- Other Identifier
- 991019167650804721
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- Web of Science research areas
- Pediatrics