Journal article
Usefulness of Handgrip Strength to Predict Mortality in Patients With Coronary Artery Disease
The American journal of cardiology, v 129, pp 5-9
15 Aug 2020
PMID: 32580913
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Handgrip strength (HGS) is a validated and simple technique to estimate skeletal muscular strength. Whether HGS is a predictor of overall mortality in patients with established coronary artery disease (CAD) is not known, this question is therefore addressed in the present study. We prospectively investigated a cohort of 691 patients with angiographically proven CAD. HGS was measured at baseline, and all-cause death as well as cardiovascular events was recorded over a period of up to 12 years. During a follow-up time of 9.2 +/- 3.1 years, 31.3% (n = 216) of the study participants died. Further, 27.8% (n = 192) suffered major cardiovascular events and 56.6% (n = 391) any cardiovascular event. Cox proportional hazard model analysis showed a reduced mortality risk with higher HGS univariately (hazard ratio [HR] for each 5 kg increase in HGS 0.87 [95% confidence interval 0.82 to 0.92]; p <0.001), after adjustment for age and gender (HR 0.86 [0.79 to 0.94]; p = 0.001), and after further adjustment for conventional cardiovascular risk factors (HR 0.86 [0.79 to 0.94]; p = 0.001). Similarly, high HGS was protective of major cardiovascular events as well as of total cardiovascular events (HRs in the fully adjusted model 0.86 [0.78 to 0.94]; p = 0.002 and 0.89 [0.83 to 0.96]; p = 0.002, respectively). From these data, we conclude that HGS is an independent predictor of overall survival and of cardiovascular events in patients with CAD.
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Details
- Title
- Usefulness of Handgrip Strength to Predict Mortality in Patients With Coronary Artery Disease
- Creators
- Barbara Larcher - Private University in the Principality of LiechtensteinDaniela Zanolin-Purin - Vorarlberg Institute for Vascular Investigation and TreatmentAlexander Vonbank - Private University in the Principality of LiechtensteinChristine F. Heinzle - Vorarlberg Institute for Vascular Investigation and TreatmentArthur Mader - Vorarlberg Institute for Vascular Investigation and TreatmentSimon Sternbauer - Private University in the Principality of LiechtensteinHeinz Drexel - Drexel University, College of MedicineChristoph H. Saely - Vorarlberg Institute for Vascular Investigation and Treatment
- Publication Details
- The American journal of cardiology, v 129, pp 5-9
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- 14159 / "Jubilaumsfonds" of the Austrian National Bank Institute for Clinical Chemistry at the Academic Teaching Hospital Feldkirch Dr. Karl Josef Hier Stiftung Land Vorarlberg
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000553464500002
- Scopus ID
- 2-s2.0-85086725310
- Other Identifier
- 991021860773804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems