Journal article
Usefulness of electrophysiologic testing in evaluation of amiodarone therapy for sustained ventricular tachyarrhythmias associated with coronary heart disease
The American journal of cardiology, v 55(4), pp 367-371
1985
PMID: 3969870
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The prognostic importance of electrophysiologic studies in patients with sustained ventricular tachyarrhythmias treated with amiodarone was prospectively studied in 100 consecutive patients. Sustained ventricular tachycardia (VT)/ventricular fibrillation (VF) was inducible in all patients before amiodarone therapy. After amiodarone administration 2 groups of patients were identified. In group 1 patients the ventricular tachyarrhythmia was no longer inducible and in group 2 patients the arrhythmia remained inducible. In group 1, no recurrent arrhythmia occurred during a follow-up of 18 ± 10 months. In group 2, 38 of 80 patients (48%) had arrhythmia recurrence during a follow-up of 12 ± 9 months. The difference between group 1 and 2 could not be explained by clinical variables, amiodarone doses or plasma concentrations, or electrocardiographic variables. In patients in whom cardiovascular collapse or other severe symptoms where noted during electrophysiologic study after amiodarone treatment, recurrences caused sudden death (n = 12). However, in patients in whom the induced arrhythmia produced moderate symptoms, the recurrent arrhythmia was nonfatal VT (n = 26). Electrophysiologic testing provides clinical guidance and predicts prognosis in patients treated with amiodarone as it does for the evaluation of other antiarrhythmic agents.
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Details
- Title
- Usefulness of electrophysiologic testing in evaluation of amiodarone therapy for sustained ventricular tachyarrhythmias associated with coronary heart disease
- Creators
- Leonard N. Horowitz - Hahnemann University HospitalAllan M. Greenspan - Hahnemann University HospitalScott R. Spielman - Hahnemann University HospitalCharles R. Webb - Hahnemann University HospitalJoel Morganroth - Hahnemann University HospitalHeschi Rotmensch - Hahnemann University HospitalNeil M. Sokoloff - Hahnemann University HospitalP. Alan RaeBernard L. SegalHarold R. Kay - Hahnemann University Hospital
- Publication Details
- The American journal of cardiology, v 55(4), pp 367-371
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1985ABD8800023
- Scopus ID
- 2-s2.0-0021984635
- Other Identifier
- 991019339696904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems