Journal article
Using distraction forces to drive an autodistractor during limb lengthening
Medical engineering & physics, v 33(8), pp 1001-1007
2011
PMID: 21531604
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Distraction osteogenesis can result in high forces developing in the limb. To determine and control the distraction forces (DF), a motorized distractor driven by feedback from DF was developed and used to lengthen the tibiae of 6 sheep undergoing distraction osteogenesis. The forces were measured continually, and, in 4 of the sheep, a force threshold was set, above which an increase in rate was initiated. The rate kept increasing to a set limit if forces remained above the threshold; otherwise, the rate was decreased. Radiographs were acquired biweekly, and muscle samples were analyzed from both the operated and contralateral limbs upon termination of the experiment. Results demonstrated a drop in DF associated with increased lengthening rate, attributed to separation of the callus as indicated by radiography. Histological evidence of muscle damage generally correlated with higher DF levels. There was a significant decrease in muscle fiber diameter in lengthened relative to contralateral limbs. Collectively, the results demonstrated the use of a force-driven distraction system and support the need for considering force data in regulating distraction rates to achieve optimal clinical outcomes.
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Details
- Title
- Using distraction forces to drive an autodistractor during limb lengthening
- Creators
- Jinyong Wee - Drexel UniversityTariq Rahman - Alfred I. duPont Hospital for ChildrenRobert E. Akins - Alfred I. duPont Hospital for ChildrenRahamim Seliktar - Drexel UniversityDavid G. Levine - Widener Hospital, the University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA 19348, USADean W. Richardson - Widener Hospital, the University of Pennsylvania School of Veterinary Medicine, 382 West Street Road, Kennett Square, PA 19348, USAGeorge R. Dodge - University of PennsylvaniaAhmed M. Thabet - Benha UniversityLaurens Holmes - Alfred I. duPont Hospital for ChildrenWilliam G. Mackenzie - Alfred I. duPont Hospital for Children
- Publication Details
- Medical engineering & physics, v 33(8), pp 1001-1007
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:000295107800015
- Scopus ID
- 2-s2.0-80051813586
- Other Identifier
- 991019167825704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical