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Journal article
Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity
Human vaccines & immunotherapeutics, v 19(3), 2267295
15 Dec 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune response, including cell players and critical signaling pathways, but many questions remain unanswered, including how the innate immune response dictates host/pathogen responses and responses to vaccines. To complicate things further, it is becoming increasingly clear that the innate immune response is not a linear pathway but is formed from complex networks and interactions. To further our understanding of the crosstalk and complexities, systems-level analyses and expanded experimental technologies are now needed. In this review, we discuss the most recent immunoprofiling techniques and discuss systems approaches to studying the global innate immune landscape which will inform on the development of personalized medicine and innovative vaccine strategies.
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Details
- Title
- Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity
- Creators
- Jennifer Connors - Drexel UniversityGina Cusimano - Drexel UniversityNathan Mege - Reading HospitalKyra Woloszczuk - Drexel UniversityEmily Konopka - Drexel UniversityMatthew Bell - Drexel UniversityDavid Joyner - Drexel UniversityJennifer Marcy - Drexel UniversityVirginie Tardif - Drexel UniversityMichele A. Kutzler - Drexel UniversityRoshell Muir - Drexel UniversityElias K. Haddad - Drexel University
- Publication Details
- Human vaccines & immunotherapeutics, v 19(3), 2267295
- Publisher
- Taylor and Francis
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Medicine (Graduate); Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:001089217200001
- Scopus ID
- 2-s2.0-85175264110
- Other Identifier
- 991021484270304721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Immunology