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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Utilizing Mechanistic Cross-Linking Technology To Study Protein–Protein Interactions: An Experiment Designed for an Undergraduate Biochemistry Lab
Journal of chemical education, v 94(3), pp 375-379
14 Mar 2017
PMID: 29255327
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Over the past decade, mechanistic cross-linking probes have been used to study protein–protein interactions in natural product biosynthetic pathways. This approach is highly interdisciplinary, combining elements of protein biochemistry, organic chemistry, and computational docking. Herein, we described the development of an experiment to engage undergraduate students in multidisciplinary research that leverages mechanistic cross-linking probes to study protein conformations and protein–protein interactions. This experiment provides students with a platform to learn chemoenzymatic synthesis, polyacrylamide gel electrophoresis, biochemical assays, and computational docking, all while exploring a contemporary biochemical topic.
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Details
- Title
- Utilizing Mechanistic Cross-Linking Technology To Study Protein–Protein Interactions: An Experiment Designed for an Undergraduate Biochemistry Lab
- Creators
- Kara Finzel - University of California, San DiegoJoris Beld - University of California San DiegoMichael D Burkart - University of California, San DiegoLouise K Charkoudian - Haverford College
- Publication Details
- Journal of chemical education, v 94(3), pp 375-379
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000397449200018
- Scopus ID
- 2-s2.0-85015788945
- Other Identifier
- 991019169708104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Education, Scientific Disciplines