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Valacyclovir-Induced Thrombotic Thrombocytopenic Purpura
Journal article   Open access   Peer reviewed

Valacyclovir-Induced Thrombotic Thrombocytopenic Purpura

Sumera Bukhari, Hafiz M Aslam, Talha A Awwal, Donald Christmas and Sara L Wallach
Curēus (Palo Alto, CA), v 12(5), 8156
16 May 2020
PMID: 32550073
url
https://doi.org/10.7759/cureus.8156View
Published, Version of Record (VoR) Open

Abstract

Hematology Internal Medicine Oncology
Valacyclovir is a well-tolerated antiviral drug. Thrombotic thrombocytopenic purpura is a rare adverse effect of valacyclovir therapy. Mostly, it has been reported in clinical trials and case reports in patients with high dose or low dose therapy in immunocompromised patients. Herein we write a case report of the immunocompetent patient, who was taking very low dose valacyclovir therapy for his recurrent genital herpes. This case emphasizes the role of low dose (1000 mg/day) valacyclovir therapy causing thrombotic thrombocytopenic purpura in an immunocompetent patient with no other explainable trigger.

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Collaboration types
Domestic collaboration
Web of Science research areas
Hematology
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