Journal article
Valence processing alterations in SAPAP3 knockout mice and human OCD
Journal of psychiatric research, Vol.151, pp.657-666
01 Jul 2022
PMID: 35661523
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abnormalities in valence processing - the processing of aversive or appetitive stimuli - may be an under recognized component of obsessive-compulsive disorder (OCD). Preclinical rodent models have been critical in furthering pathophysiological understanding of OCD, yet there is a dearth of investigations examining whether rodent models of compulsive behavior show alterations in valence systems congruent with those seen in individuals with OCD. In this study, we sought to assess valence processing in a preclinical rodent model of compulsive behavior, the SAPAP3 knockout (KO) mouse model, and compare our preclinical findings to similar behavioral phenomena in OCD patients. In SAPAP3 KO mice, we used auditory fear conditioning and extinction to examine alterations in negative valence processing and reward-based operant conditioning to examine alterations in positive valence processing. We find that SAPAP3 KO mice show evidence of heightened negative valence processing through enhanced fear learning and impaired fear extinction. SAPAP3 KO mice also show deficits in reward acquisition and goal-directed behavior, suggesting impaired positive valence processing. In OCD patients, we used validated behavioral tests to assess explicit and implicit processing of fear-related facial expressions (negative valence) and socially-rewarding happy expressions (positive valence). We find similar trends towards enhanced negative and impaired positive valence processing in OCD patients. Overall, our results reveal valence processing abnormalities in a preclinical rodent model of compulsive behavior similar to those seen in OCD patients, with implications for valence processing alterations as novel therapeutic targets across a translational research spectrum.
Metrics
2 Record Views
Details
- Title
- Valence processing alterations in SAPAP3 knockout mice and human OCD
- Creators
- Bridget L. Kajs - University of California, San FranciscoPeter J. van Roessel - VA Palo Alto Health Care SystemGwynne L. Davis - University of California, San FranciscoLeanne M. Williams - VA Palo Alto Health Care SystemCarolyn I. Rodriguez - VA Palo Alto Health Care SystemLisa A. Gunaydin - University of California, San Francisco
- Publication Details
- Journal of psychiatric research, Vol.151, pp.657-666
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Chan Zuckerberg Biohub Investigator Award; Chan Zuckerberg Initiative (CZI) Miller Foundation Award for Psychiatric Research IOCDF Break-through Award R01MH105461 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Office of Academic Affiliations, Advanced Fellowship Program in Mental Illness Research and Treatment, Department of Veterans Affairs
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000809650000007
- Scopus ID
- 2-s2.0-85131370417
- Other Identifier
- 991022058590304721
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry