Journal article
Validation of Signal Intensity Gradient from TOF-MRA for Wall Shear Stress by Phase-Contrast MR
Journal of imaging informatics in medicine, v 37(3), pp 1248-1258
01 Jun 2024
PMID: 38332403
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To validate the correlation between the signal intensity gradient (SIG) from time-of-flight magnetic resonance angiography (TOF-MRA) and wall shear stress (WSS) determined by phase contrast magnetic resonance (PC-MR), we conducted both experimental and human studies. In the experimental study, we measured WSS in four tubes of different sizes with variable flow rates using PC-MR and TOF-MRA. The flow rates of water in the experimental study ranged from 0.06 to 12.75 mL/s, resulting in PC-WSS values between 0.1 and 1.6 dyne/cm
2
. The correlation between PC-WSS and SIG was statistically significant, showing a coefficient of 0.86 (
P
< 0.001,
R
2
= 0.75). The line fit provided the conversion equation as
Y
= 1.6287
X
− 1.1563 (
Y
= PC-WSS,
X
= SIG). For the human study, 28 subjects underwent TOF-MRA and PC-MR examinations of carotid and vertebral arteries. Arterial PC-WSS and SIG were determined in the same segment for each subject. The arterial PC-WSS ranged from 1.9 to 21.0 dyne/cm
2
. Both carotid and vertebral arteries showed significant correlations between PC-WSS and SIG, with coefficients of 0.85, 0.86, 0.91, and 0.81 in the right and left carotid and vertebral arteries, respectively. Our results show that SIG from TOF-MRA and SIG-WSS derived from the conversion equation provide concurrent
in vivo
hemodynamic information on arterial shear stress. This study was registered on ClinicalTrials.gov with the identifier NCT04585971 on October 14, 2020.
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Details
- Title
- Validation of Signal Intensity Gradient from TOF-MRA for Wall Shear Stress by Phase-Contrast MR
- Creators
- Chan-Hyuk Lee - Asan Medical CenterSang Hyuk Lee - Korea Institute of Machinery & MaterialsHyo-Sung Kwak - Jeonbuk National University HospitalYeong-Gon Kwak - WonKwang Health Science UniversityRobert S. Rosenson - Icahn School of Medicine at Mount SinaiYoung I. Cho - Drexel UniversitySeul-Ki Jeong - Seul-Ki Jeong Neurology Clinic, 233, Gucheonmyeon-ro, Gangdong-gu, Seoul, 05326 Republic of Korea
- Publication Details
- Journal of imaging informatics in medicine, v 37(3), pp 1248-1258
- Publisher
- Springer Nature
- Number of pages
- 11
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- C. and J. Nyheim Plasma Institute; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001248218600007
- Scopus ID
- 2-s2.0-105007716326
- Other Identifier
- 991022092338104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging