Journal article
Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow
IEEE transactions on biomedical engineering, v 55(2), pp 643-649
01 Feb 2008
PMID: 18270000
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The drug-eluting stent's increasingly frequent occurrence late stage thrombosis have created a need for new strategies for intervention in coronary artery disease. This paper demonstrates further development of our minimally invasive, targeted drug delivery system that uses induced magnetism to administer repeatable and patient specific dosages of therapeutic agents to specific sites in the human body. Our first, aim is the use of magnetizable stents for the prevention and treatment of coronary restenosis; however, future applications include the targeting of tumors, vascular defects, and other localized pathologies. Future doses can be administered to the same site by intravenous injection. This implant-based drug delivery system functions by placement of a weakly magnetizable stent or implant at precise locations in the cardiovascular system, followed by the delivery of magnetically susceptible drug carriers. The stents are capable of applying high local magnetic field gradients within the body, while only exposing the body to a modest external field. The local gradients created within the blood vessel create the forces needed to attract and hold drug-containing magnetic nanoparticles at the implant site. Once these particles are captured, they are capable of delivering therapeutic agents. such as antineoplastics, radioactivity, or biological cells.
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Details
- Title
- Validation of high gradient magnetic field based drug delivery to magnetizable implants under flow
- Creators
- Zachary G. Forbes - Drexel Univ, Coll Med, Dept Surg, Philadelphia, PA 19102 USABenjamin B. Yellen - Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USADerek S. Halverson - Drexel Univ, Dept Elect & Comp Engn, Philadelphia, PA 19104 USAGregory Fridman - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAKenneth A. Barbee - Drexel University, School of Biomedical Engineering, Science, and Health SystemsGary Friedman - Drexel University, Electrical and Computer Engineering
- Publication Details
- IEEE transactions on biomedical engineering, v 55(2), pp 643-649
- Publisher
- IEEE
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; School of Biomedical Engineering, Science, and Health Systems; College of Engineering
- Web of Science ID
- WOS:000252622200027
- Scopus ID
- 2-s2.0-38349054674
- Other Identifier
- 991014632197404721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical