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Journal article
Validity of Self-Assessed Sexual Maturation Against Physician Assessments and Hormone Levels
The Journal of pediatrics, v 186, pp 172-178
Jul 2017
PMID: 28438374
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To compare self-report and physician assessments of sexual maturation against serum hormone markers to evaluate the hypothesis that the validity of self-assessed sexual maturation is underestimated in traditional validation studies.
We adapted a self-assessment instrument that 248 Mexican children and adolescents, aged 8-13 years, completed. The participants were examined by a trained pediatrician and provided fasting blood samples for measurement of reproductive hormones (eg, testosterone, estradiol, sex hormone-binding globulin, inhibin B) and other hormones (eg, C-peptide, insulin-like growth factor 1, leptin, dehydroepiandrosterone sulfate) known to change during adolescence. Spearman correlations (r) were calculated among the average rank of all hormones and self-assessed and physician-assessed Tanner stage. The method of triads was used to assess the validity of self-reports by estimating correlations between self-assessments and true but unobservable sexual maturation based on all available data. Bootstrap sampling was used to construct 95% CIs.
The validity of self-reported genitalia staging for boys was modest (r = 0.50; 95% CI, 0.31-0.65) and inferior to physician assessment (r = 0.75; 95% CI, 0.56-0.93). Breast stage was well reported (r = 0.89; 95% CI, 0.79-0.97) and superior to physician assessment (r = 0.80; 95% CI, 0.70-0.89). Pubic hair stage reported by boys (r = 0.91; 95% CI, 0.79-0.99) and girls (r = 0.99; 95% CI, 0.96-1.00) was superior to physician assessment (r = 0.79; 95% CI, 0.57-0.97 and r = 0.91; 95% CI, 0.83-0.97, respectively).
Self-assessment can be validly used in epidemiologic studies for evaluating sexual maturation in children; however, physician assessment may be necessary for accurate assessment of genitalia development in boys.
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Details
- Title
- Validity of Self-Assessed Sexual Maturation Against Physician Assessments and Hormone Levels
- Creators
- Jorge E. Chavarro - Harvard UniversityDeborah J. Watkins - University of MichiganMyriam C. Afeiche - Harvard UniversityZhenzhen Zhang - University of MichiganBrisa N. Sánchez - University of MichiganDavid Cantonwine - Brigham and Women's HospitalAdriana Mercado-García - Instituto Nacional de Salud PúblicaClara Blank-Goldenberg - American British Cowdray Medical Center, Mexico City, DF, Mexico.John D. Meeker - University of MichiganMartha María Téllez-Rojo - Instituto Nacional de Salud PúblicaKaren E. Peterson - Harvard University
- Publication Details
- The Journal of pediatrics, v 186, pp 172-178
- Publisher
- Elsevier
- Grant note
- P20 ES018171/RD834800 / NIEHS/EPA Formative Children's Environmental Health and Disease Prevention Center R01 ES007821; R01 ES021446; R01 ES014930; R01 ES013744; P01 ES012874; P30 ES017885 / National Institute of Environmental Health Sciences (http://dx.doi.org/10.13039/100000066) 37210-M; 29192-M; 41912-M / Consejo Nacional de Ciencia y Tecnología (http://dx.doi.org/10.13039/501100003141) RD-83172501 / US Environmental Protection Agency (http://dx.doi.org/10.13039/100000139) P01 ES02284401/RD 83543601 / NIEHS/EPA Children's Environmental Health and Disease Prevention Center
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000405901300035
- Scopus ID
- 2-s2.0-85018627415
- Other Identifier
- 991020100200004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics