Journal article
Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure
The Annals of occupational hygiene, v 59(5), pp 609-615
Jun 2015
PMID: 25737332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Assessment of retrospective exposures based on expert judgment in case-control studies is usually of unknown validity because of the difficulty in finding gold standards for comparison. We investigated the relationship between expert-assigned retrospective occupational polychlorinated biphenyl (PCB) exposure estimates and serum PCB concentrations. Analyses were conducted on a subset of cases (n = 94) and controls (n = 96) in the multi-center National Cancer Institute, Surveillance, Epidemiology, and End Results Case-Control Study of non-Hodgkin lymphoma. Based on the subjects' lifetime work histories, an industrial hygienist assigned each job a probability of PCB exposure [<5% (unexposed), 5-<50% (possibly exposed), ≥50% (probably exposed)]. Ordinary least squares regression was used to investigate associations between the probability rating and log-transformed lipid-adjusted serum levels of 14 PCB congeners and total PCBs (ΓPCBs). Compared to unexposed participants (n = 163), those with a probably exposed job (n = 7) had serum levels that were 87% higher for ΓPCBs (95% confidence interval: 1.33-2.62) and 38% of serum level variability was explained by the probability rating. Statistically significant associations between probability ratings and serum levels for 12 of 14 individual congeners were also observed. In summary, the observed contrast in PCB serum levels by probability rating provides support for the occupational PCB exposure assessment.
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Details
- Title
- Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure
- Creators
- Curt T DellaValle - National Cancer InstituteMark P Purdue - National Cancer InstituteMary H Ward - National Cancer InstituteSarah J Locke - National Cancer InstitutePatricia A Stewart - 2.Stewart Exposure Assessments, LLC, Arlington, VA 22207, USA#N#Anneclaire J De Roos - Drexel UniversityPatricia Hartge - 4.Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.Nathanial Rothman - National Cancer InstituteMelissa C Friesen - National Cancer Institute
- Publication Details
- The Annals of occupational hygiene, v 59(5), pp 609-615
- Publisher
- Oxford University Press
- Grant note
- Z01 CP010120 / NCI NIH HHS Intramural NIH HHS Z01 CP10122 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000356627300009
- Scopus ID
- 2-s2.0-84941619436
- Other Identifier
- 991019168298204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Toxicology