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Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists
Journal article   Open access   Peer reviewed

Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists

Takefumi Uchida, Philip O Scumpia, Donna M Murasko, Shuhji Seki, Susan Woulfe, Michael J Clare-Salzler and Lyle L Moldawer
The Journal of immunology (1950), v 178(6), pp 3886-3892
15 Mar 2007
DOI: https://doi.org/10.4049/jimmunol.178.6.3886
PMID: 17339488
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4049/jimmunol.178.6.3886View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Abridged Index Medicus
TLRs initiate the host immune response to microbial pathogens by activating cells of the innate immune system. Dendritic cells (DCs) can be categorized into two major groups, conventional DCs (including CD8(+) and CD8(-) DCs) and plasmacytoid DCs. In mice, these subsets of DCs express a variety of TLRs, with conventional DCs responding in vitro to predominantly TLR3, TLR4, TLR5, and TLR9 ligands, and plasmacytoid DCs responding mainly to TLR7 and TLR9 ligands. However, the in vivo requirement of DCs to initiate immune responses to specific TLR agonists is not fully known. Using mice depleted of >90% of CD11c(+) MHC class II(+) DCs, we demonstrate that cellular recruitment, including CD4(+) T cell and CX5(+)DX5(+) NK cell recruitment to draining lymph nodes following the footpad administration of TLR4 and TLR5 agonists, is dramatically decreased upon reduction of DC numbers, but type I IFN production can partially substitute for DCs in response to TLR3 and TLR7 agonists. Interestingly, TLR ligands can activate T cells and NK cells in the draining lymph nodes, even with reduced DC numbers. The findings reveal considerable plasticity in the response to TLR agonists, with TLR4 and TLR5 agonists sharing the requirement of DCs for subsequent lymph node recruitment of NK and T cells.

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9 citations in Web of Science
10 citations in Scopus

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Immunology
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