Journal article
Variation in C-reactive protein at 1 month post-partum by etiology of preterm birth: selective identification of those at risk for both poor pregnancy outcome and future health complications
Journal of perinatal medicine, v 47(8), pp 804-810
25 Oct 2019
PMID: 31494638
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective To assess post-partum inflammation for patients delivering prior to 34 6/7 weeks by birth etiology. Methods This was an observational study of early preterm birth (PTB) occurring between 20 0/7 and 34 6/7 weeks of gestation. Serum C-reactive protein (CRP) levels were measured 1 month post-partum. CRP measurements were compared by birth etiology. Results A total of 399 women were analyzed. Distribution of birth etiology was 35% (n = 138) preterm labor (PTL), 28% (n = 115) preterm premature rupture of membranes (pPROM), and 37% (n = 141) indicated preterm birth (IPTB). Serum CRP varied by birth etiology (P = 0.036). Women with pPROM had elevated median CRP levels compared to women with PTL (P = 0.037). IPTB demonstrated elevated CRP levels when compared to PTL (P = 0.019). Pre-eclamptic/eclamptic subjects exhibited increased median CRP levels compared to PTL (P = 0.04). Conclusion Post-partum inflammation varies by birth etiology. Such variation may serve as identification of subjects whose future pregnancies and, ultimately, overall health status may benefit from inter-pregnancy interventions aimed at reducing inflammatory-associated risk factors.
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Details
- Title
- Variation in C-reactive protein at 1 month post-partum by etiology of preterm birth: selective identification of those at risk for both poor pregnancy outcome and future health complications
- Creators
- Jeffrey M Denney - Drexel UniversityThaddeus P Waters - Drexel UniversityLeny Mathew - Children's Hospital of PhiladelphiaRobert Goldenberg - Drexel UniversityJennifer Culhane - Drexel University
- Publication Details
- Journal of perinatal medicine, v 47(8), pp 804-810
- Publisher
- De Gruyter
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000489123200002
- Scopus ID
- 2-s2.0-85072314113
- Other Identifier
- 991019339568304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics