Journal article
Variation in Effects of Non-Hodgkin Lymphoma Risk Factors According to the Human Leukocyte Antigen (HLA)-DRB101:01 Allele and Ancestral Haplotype 8.1
PloS one, v 6(11), pp e26949-e26949
09 Nov 2011
PMID: 22096508
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Genetic variations in human leukocyte antigens (
HLA
) are critical in host responses to infections, transplantation, and immunological diseases. We previously identified associations with non-Hodgkin lymphoma (NHL) and the
HLA-DRB1*01:01
allele and extended ancestral haplotype (AH) 8.1 (
HLA-A*01-B*08-DR*03-TNF-308A
). To illuminate how
HLA
alleles and haplotypes may influence NHL etiology, we examined potential interactions between
HLA-DRB1*01:01
and AH 8.1, and a wide range of NHL risk factors among 685 NHL cases and 646 controls from a United States population-based case-control study. We calculated odds ratios and 95% confidence intervals by
HLA
allele or haplotype status, adjusted for sex, age, race and study center for NHL and two major subtypes using polychotomous unconditional logistic regression models. The previously reported elevation in NHL risk associated with exposures to termite treatment and polychlorinated biphenyls were restricted to individuals who did
not
possess
HLA-DRB1*01:01
. Previous associations for NHL and DLBCL with decreased sun exposure, higher BMI, and autoimmune conditions were statistically significant only among those
with
AH 8.1, and null among those
without
AH 8.1. Our results suggest that NHL risk factors vary in their association based on
HLA-DRB1*01:01
and AH 8.1 status. Our results further suggest that certain NHL risk factors may act through a common mechanism to alter NHL risk. Finally, control participants with either
HLA-DRB1*01:01
or AH 8.1 reported having a family history of NHL twice as likely as those who did not have either allele or haplotype, providing the first empirical evidence that
HLA
associations may explain some of the well-established relationship between family history and NHL risk.
Metrics
Details
- Title
- Variation in Effects of Non-Hodgkin Lymphoma Risk Factors According to the Human Leukocyte Antigen (HLA)-DRB101:01 Allele and Ancestral Haplotype 8.1
- Creators
- Sophia S. Wang - City Of Hope National Medical CenterYani Lu - City Of Hope National Medical CenterNathaniel Rothman - National Institutes of HealthAmr M. Abdou - National Research CenterJames R. Cerhan - Mayo ClinicAnneclaire De Roos - University of WashingtonScott Davis - University of WashingtonRichard K. Severson - Wayne State UniversityWendy Cozen - University of Southern CaliforniaStephen J. Chanock - National Institutes of HealthLeslie Bernstein - City Of Hope National Medical CenterLindsay M. Morton - National Institutes of HealthPatricia Hartge - National Institutes of Health
- Publication Details
- PloS one, v 6(11), pp e26949-e26949
- Publisher
- Public Library of Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000297350800017
- Scopus ID
- 2-s2.0-80655139024
- Other Identifier
- 991020099895704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology