Journal article
Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites
Journal of biochemical and molecular toxicology, v 27(1), pp 87-97
Jan 2013
PMID: 23335408
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spatial variation in particulate matter–related health and toxicological outcomes is partly due to its composition. We studied spatial variability in particle composition and induced cellular responses in Mexico City to complement an ongoing epidemiologic study. We measured elements, endotoxins, and polycyclic aromatic hydrocarbons in two particle size fractions collected in five sites. We compared the in vitro proinflammatory response of J774A.1 and THP-1 cells after exposure to particles, measuring subsequent TNF
α
and IL-6 secretion. Particle composition varied by site and size. Particle constituents were subjected to principal component analysis, identifying three components: C
1
(Si, Sr, Mg, Ca, Al, Fe, Mn, endotoxin), C
2
(polycyclic aromatic hydrocarbons), and C
3
(Zn, S, Sb, Ni, Cu, Pb). Induced TNF
α
levels were higher and more heterogeneous than IL-6 levels. Cytokines produced by both cell lines only correlated with C
1
, suggesting that constituents associated with soil induced the inflammatory response and explain observed spatial differences.
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Details
- Title
- Variation in the Composition and In Vitro Proinflammatory Effect of Urban Particulate Matter from Different Sites
- Creators
- Natalia Manzano-León - Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080, México, D.F., MéxicoRaúl Quintana - Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080, México, D.F., MéxicoBrisa Sánchez - Departments of Environmental Health Sciences and Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USAJesús Serrano - Facultad de Ciencias, Universidad Nacional Autónoma de México, C.P. 04510, México, D.F. MéxicoElizabeth Vega - Instituto Mexicano del Petroleo, Eje Central Lázaro Cárdenas 152, Edif. 27D, Cubículo 110, San Bartolo Atepehuacan, C.P. 07730, México, D.F. MéxicoInés Vázquez-López - Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080, México, D.F., MéxicoLeonora Rojas-Bracho - Instituto Nacional de Ecología, Periférico Sur 5000, 4to piso, Col. Insurgentes Cuicuilco, C.P. 04530, México, D.F. MéxicoTania López-Villegas - Instituto Nacional de Ecología, Periférico Sur 5000, 4to piso, Col. Insurgentes Cuicuilco, C.P. 04530, México, D.F. MéxicoMarie S O’Neill - Departments of Environmental Health Sciences and Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USAFelipe Vadillo-Ortega - Universidad Nacional Autónoma de México, Branch at National Institute of Genomic Medicine, Periferico Sur 4809, Col. Arenal Tepepan, C.P. 14610, México, D.F. MéxicoAndrea De Vizcaya-Ruiz - Departamento de Toxicología, Cinvestav, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, C.P. 07360, México, D.F. MéxicoIrma Rosas - Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, Circuito Exterior s/n. Ciudad Universitaria, Del. Coyoacán, C.P. 04510, México, D.F. MéxicoÁlvaro R Osornio-Vargas - Instituto Nacional de Cancerología, Av. San Fernando 22, Col. Sección XVI, C.P. 14080, México, D.F., México
- Publication Details
- Journal of biochemical and molecular toxicology, v 27(1), pp 87-97
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000313777200010
- Scopus ID
- 2-s2.0-84872508825
- Other Identifier
- 991014878173104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Toxicology