Journal article
Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species
American journal of obstetrics and gynecology, v 195(2), pp 516-521
2006
PMID: 16643824
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study was undertaken to assess if levels of interleukin-1β (IL-1β), IL-8, sialidase, prolidase and immunoglobulin A against
Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ between BV+ women with (M+) and without (M−)
Mobiluncus spp.
Vaginal secretions were obtained from 265 women at their first prenatal care visit and assessed for all study parameters. Gram stain evaluation using Nugent criteria was performed and coinfection with sexually transmitted infections determined. Differences between BV+/M+ and BV+/M− women were evaluated using the χ
2 statistic or Mann-Whitney test.
Of the 265 BV+ women, 43% (n = 113) were M+ of which 97% (n = 110) had Nugent scores of 9 or 10 . BV+/M+ women had elevated levels of sialidase (median value: 4.11 nmol vs 1.91 nmol of converted substrate;
P = .003) but no difference in prolidase, anti-Gvh IgA, IL-1β, IL-8, levels were found between the two groups. BV+/M− women had significantly higher rates of coinfection with
Trichomonas vaginalis.
BV+/M+ women have higher vaginal concentrations of sialidase and lower rates of
T vaginalis compared with BV+/M− women. Further research is needed to assess the association of this, and other, microbiologic profiles to risk of adverse pregnancy outcome.
Metrics
Details
- Title
- Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species
- Creators
- Jennifer F. Culhane - Drexel UniversityPaul Nyirjesy - Drexel UniversityKelly McCollum - Drexel UniversityRobert L. Goldenberg - University of Alabama at BirminghamShari E. Gelber - Drexel UniversitySabina Cauci - University of Udine
- Publication Details
- American journal of obstetrics and gynecology, v 195(2), pp 516-521
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000239638000027
- Scopus ID
- 2-s2.0-33746475106
- Other Identifier
- 991019339695404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology