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Journal article
Variations and Asymmetry in Sacral Ventral Rami Contributions to the Bladder
Diagnostics (Basel), v 15(1), 102
03 Jan 2025
PMID: 39795630
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Abstract
AbstractBackground/Objectives: We have demonstrated in human cadavers and canines that nerve transfer to bladder vesical nerve branches is technically feasible for bladder reinnervation after nerve injury. We further clarify here that sacral (S) ventral rami contribute to these vesical branches in 36 pelvic sides (in 22 human cadavers). Methods: Gross post-mortem visualization and open anterior abdominal approaches were used, as was micro-CT of sacral nerve bundles, for further confirmation when needed. Results: Considerable between and within-subject variation was observed. Sacral (S) ventral rami contributions to vesical nerves were observed as shared contributions from several rami or, in a few cases, from single rami: S2 alone (6%), S3 alone (6%), S2 and S3 (28%), S3 and S4 (28%), S2–S4, 14%, L5 in combination with S1–S4 (6%), S1 and S2 (6%), and S3–S5 (3%). The most common contributor to these shared or single rami contributions was from the S3 ventral ramus, which contributed 100% of the time on the left side and 79% on the right side. Side-to-side asymmetry was observed in 10 of 14 cadavers examined bilaterally (71%). Conclusions: This characterization of the anatomical variation in sacral ventral rami contributions to the bladder will ultimately aid in developing therapeutics for patients with bladder dysfunction.
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Details
- Title
- Variations and Asymmetry in Sacral Ventral Rami Contributions to the Bladder
- Creators
- Rebeccah Overton - Temple UniversityIstvan Tamas - Temple UniversityEmily Day (Corresponding Author) - Drexel University, College of MedicineNagat Frara - Temple UniversityMichel Pontari - Temple UniversitySusan Fecho - Barton CollegeSteven Popoff - Temple UniversityMary Barbe
- Publication Details
- Diagnostics (Basel), v 15(1), 102
- Publisher
- MDPI
- Number of pages
- 17
- Grant note
- National Institute of Neurological Disorders and Stroke: NS070267 National Institute of Neurological Disorders and Stroke GrantDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine of Temple University, Philadelphia, PA, USA
This research was funded by the National Institute of Neurological Disorders and Stroke Grant NS070267 (to M.F.B.) and the Department of Biomedical Education and Data Science, Lewis Katz School of Medicine of Temple University, Philadelphia, PA, USA.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001393945600001
- Scopus ID
- 2-s2.0-85214448322
- Other Identifier
- 991022017598604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology