Logo image
Back
Varying role of alpha/beta interferon in the antiviral efficacy of synthetic immunomodulators against semliki forest virus infection
Journal article   Peer reviewed

Varying role of alpha/beta interferon in the antiviral efficacy of synthetic immunomodulators against semliki forest virus infection

Page S. Morahan, Angelo Pinto, Deneen Stewart, Donna M. Murasko and Margo A. Brinton
Antiviral research, v 15(3), pp 241-254
1991
DOI: https://doi.org/10.1016/0166-3542(91)90070-8
PMID: 1653557
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

ABMP Ampligen Anti-interferon serum CL246,738 Interferon MVE-2 Poly ICLC Semliki Forest virus
The question of whether interferon alpha/beta is the common mechanism of antiviral action of synthetic immunomodulators was investigated in B6C3F1 mice infected with Semliki Forest virus. Mice were treated with various concentrations of normal sheep serum or potent anti-alpha/beta interferon antiserum, inoculated with the immunomodulators, and infected 24 hours later with virus. Three patterns emerged. The antiviral action of the pyrimidinone (ABMP) and the oral interferon inducer (CL246,738) appeared to be mediated primarily by interferon alpha/beta; their protective ability was almost completely abrogated by treatment with low levels of anti-alpha/beta interferon antiserum. The antiviral action of two other immunomodulators, a mismatched polyribonucleotide (Ampligen) and a polyanionic copolymer (MVE-2) at least partially involved interferon. Activity of these compounds was reduced, but not consistently eliminated by treatments with high doses of antiserum. The antiviral activity of another polyribonucleotide, polyriboinosinic-cytidylic acid complexed with lysine carboxymethylcellulose (poly ICLC), was not affected by treatment with even the highest amount of antiserum (two injections of 100000 neutralizing units each). Almost complete protection by poly ICLC was observed despite the fact that this high concentration of antiserum, when given alone, caused a decrease in natural resistance to Semliki Forest virus infection. Taken together, these results indicate that induction of interferon alpha/beta does not appear to be the major common mechanism of antiviral activity among these diverse synthetic immunomodulators.

Metrics

4 Record Views
17 citations in Web of Science
16 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Pharmacology & Pharmacy
Virology
Logo image