Journal article
Vascular placental pathology and the relationship between hypertensive disorders of pregnancy and neonatal outcomes in very low birth weight infants
Journal of perinatology, v 38(4), pp 324-331
Apr 2018
PMID: 29311628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To investigate vascular placental pathology's effect on known associations between hypertensive disorders and four adverse neonatal outcomes-bronchopulmonary dysplasia, intraventricular hemorrhage or periventricular leukomalacia, necrotizing enterocolitis, and death.
Retrospective cohort of very low birth weight neonates born at a single center (n = 911). Statistical analysis included χ
, t test, modified Poisson regression with robust error variance to measure risk, and Wald test. Stratified models assessed the effect of maternal hypertension on neonatal outcomes in those exposed to placental pathology.
Neonates exposed to maternal hypertension and placental pathology had an increased risk of bronchopulmonary dysplasia (relative risk (RR) = 5.23, 95% confidence interval (CI): 2.07, 13.22) compared to those exposed to hypertension without placental pathology (RR = 1.63, 95% CI: 1.14, 2.34; Wald test p = 0.02). Similar, but non-significant, trends also emerged for necrotizing enterocolitis and death.
Vascular placental pathology may amplify the risk of adverse outcomes in neonates exposed to hypertension and may mark the extent to which hypertension affects neonates.
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Details
- Title
- Vascular placental pathology and the relationship between hypertensive disorders of pregnancy and neonatal outcomes in very low birth weight infants
- Creators
- Lisa Strouss - Christiana Care Health SystemNeal D Goldstein - Drexel UniversityRobert Locke - Christiana Care Health SystemDavid A Paul - Christiana Care Health System
- Publication Details
- Journal of perinatology, v 38(4), pp 324-331
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000432281900005
- Scopus ID
- 2-s2.0-85047061142
- Other Identifier
- 991019168000604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics