Journal article
Vasoactive agonists prevent erythrocyte extravasation in thrombocytopenic hamsters
Thrombosis research, v 35(4), pp 421-430
1984
PMID: 6484891
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The mediating action of selected vasoactive amines and their respective antagonists on vascular fragility, visible as cutaneous petechiae, was assayed with thrombocytopenic (TCP) hamsters. Serotonin (5-HT), norepinephrine (NE), epinephrine, dopamine and isoproterenol administered IP reduced petechiae significantly within 10 min; phenylephrine had no effect. Of the natural amines, 5-HT and NE were most effective in reducing petechial sensitivity to values obtained with untreated, normal animals; hence these two amines only were tested pharmacologically. Pretreatment of TCP animals with Ketanserin or propranolol, administered IP or IV, abolished any petechial inhibitory action of 5-HT and NE respectively; pretreatment with phenoxybenzamine reduced significantly the NE inhibition of petechiae, but to a lesser degree than propranolol. In contrast, atenolol, prazosin and yohimbine had no significant effect. Ketanserin abolished the action of NE, but adrenoceptor blockers had no effect on 5-HT-treated TCP hamsters. The results suggest that 5-HT and NE inhibition of petechiae may be receptor-mediated and that there may be receptor interaction. This was supported by the observation that non-additive subthreshold doses of 5-HT and NE, which individually did not prevent petechial formation in TCP hamsters, when combined totally inhibited petechiae. The theorized importance of endogenous 5-HT and NE to maintain postcapillary venule junctional integrity (site of petechial hemorrhaging) was also demonstrated by treating normal hamsters with drugs known to block or antagonize either 5-HT or NE uptake. In every instance petechial sensitivity rapidly occurred, and the loss of microvascular integrity in Ketanserin-treated hamsters mimicked quantitatively the petechial sensitivity observed with TCP animals.
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Details
- Title
- Vasoactive agonists prevent erythrocyte extravasation in thrombocytopenic hamsters
- Creators
- David Shepro - Departments of Biology and Surgery, Boston University, Boston, MA USASeth L Welles - Departments of Biology and Surgery, Boston University, Boston, MA USAHerbert B Hechtman - Department of Surgery, Brigham and Women's Hospital, Harvard University, Boston, MA, USA
- Publication Details
- Thrombosis research, v 35(4), pp 421-430
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:A1984TD31600006
- Scopus ID
- 2-s2.0-0021163685
- Other Identifier
- 991014878509904721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Peripheral Vascular Disease