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Journal article
Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study
American journal of Alzheimer's disease and other dementias, v 30(6), pp 622-628
01 Sep 2015
PMID: 25788434
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements.
The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained.
Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor.
These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.
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Details
- Title
- Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study
- Creators
- David J Libon - Drexel UniversitySarah R Preis - Boston UniversityAlexa S Beiser - Boston UniversitySherral Devine - Boston UniversitySudha Seshadri - Boston UniversityPhilip A Wolf - Boston UniversityCharles DeCarli - University of California, DavisRhoda Au - Boston University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 30(6), pp 622-628
- Publisher
- Sage
- Grant note
- R01 AG016495 / NIA NIH HHS R01-NS17950 / NINDS NIH HHS N01HC25195 / NHLBI NIH HHS N01-HC-25195 / NHLBI NIH HHS R01 AG033040 / NIA NIH HHS R01-AG033040 / NIA NIH HHS R01-AG16495 / NIA NIH HHS R01 AG008122 / NIA NIH HHS R01 NS017950 / NINDS NIH HHS R01-AG08122 / NIA NIH HHS P30 AG010129 / NIA NIH HHS R01 AG042292 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000359724800011
- Scopus ID
- 2-s2.0-84939187877
- Other Identifier
- 991021901313504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Geriatrics & Gerontology