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Very High-Dose Streptomycin Labyrinthectomy
Journal article   Peer reviewed

Very High-Dose Streptomycin Labyrinthectomy

Robert Thayer Sataloff, Anne McCarter and Joseph R. Spiegel
Ear, nose, & throat journal, v 75(4), pp 239-243
Apr 1996
PMID: 8935647

Abstract

Medical labyrinthectomy by systemic administration of streptomycin has proven safe and effective for treatment of selected patients with intractable vertigo. In most patients, 40 grams or less of streptomycin sulfate are required. However, otolaryngologists should be aware that much higher doses can be used safely in selected patients; and a small number of patients may be resistant to streptomycin toxicity even in doses over 100 grams.

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