Journal article
Viability of chlamydia trachomatis in fallopian tubes of patients with ectopic pregnancy
Fertility and sterility, v 70(5), pp 945-948
1998
PMID: 9806581
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To use standard molecular methods to define the prevalence and metabolic characteristics of
Chlamydia trachomatis during infection of fallopian tubes in women with ectopic pregnancies.
Design: Polymerase chain reaction (PCR)- and reverse transcription-PCR (RT-PCR)-based assessment of presence of chlamydial DNA and various RNA species in fallopian tube biopsy samples.
Setting: Hospital and molecular genetics laboratory.
Patients: Ten women of varying ages, each presenting with ectopic pregnancy.
Main Outcome Measure(s): Positive signal in specific chlamydia-directed PCR and RT-PCR assays.
Result(s): Nucleic acid preparations from 7 of the 10 fallopian tube patient samples were PCR-positive for
C. trachomatis DNA. Each of the 7 PCR-positive samples also showed the presence of several transcripts from the bacterium, including primary transcripts from the ribosomal RNA operons.
Conclusion(s): A higher proportion of ectopic pregnancies than was believed previously may be attributable to infection of the fallopian tubes by
C. trachomatis. The presence of various chlamydial RNA molecules suggests that viable, metabolically active bacteria were present in fallopian tubes of the patients studied.
Metrics
Details
- Title
- Viability of chlamydia trachomatis in fallopian tubes of patients with ectopic pregnancy
- Creators
- Hervé C Gérard - Wayne State UniversityPatrick J Branigan - Hahnemann University HospitalGulnar R Balsara - Allegheny University of the Health SciencesChristine Heath - Allegheny University of the Health SciencesShahab S Minassian - Allegheny University of the Health SciencesAlan P Hudson - Wayne State University
- Publication Details
- Fertility and sterility, v 70(5), pp 945-948
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:000076749600026
- Scopus ID
- 2-s2.0-0032211857
- Other Identifier
- 991019167792404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology