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Viral, Host and Environmental Risk Factors for Hepatocellular Carcinoma: A Prospective Study in Haimen City, China
Journal article   Peer reviewed

Viral, Host and Environmental Risk Factors for Hepatocellular Carcinoma: A Prospective Study in Haimen City, China

Thomas London, Alison A Evans, Katherine McGlynn, Kenneth Buetow, Ping An, Long-long Gao, Edward Lustbader, Eric Ross, Gong-chao Chen and Fu-min Shen
Intervirology, v 38(3-4), pp 155-161
1995
DOI: https://doi.org/10.1159/000150426
PMID: 8682610
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

HBV and HCV
To identify specific environmental, viral, and genetic risk factors for hepatocellular carcinoma (HCC) and the interaction of such factors, we are conducting a prospective study in a high-incidence area of China. Questionnaires were completed and biosamples collected by 60,984 men ages 30-64 years, at study entry. Within 2.5 years, 183 deaths from HCC had occurred. Each HCC case was matched with 5 controls and compared for items on the questionnaire. In addition to chronic hepatitis B virus (HBV) infection, the significant risk factors were: occupation (peasant), corn consumption (in the 1970s), family history of HCC, and history of an episode of acute hepatitis as an adult. HBV, consumption of aflatoxins, a genetic factor, and possibly a second hepatitis virus infection contribute to the risk of HCC.

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52 citations in Web of Science
57 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Virology
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