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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections
Antiviral therapy, v 20(3)
01 Jan 2015
PMID: 25318123
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sadat et al. reported in the 24 April 2014 issue of the New England Journal of Medicine that patients genetically deficient in the gene encoding mannosyl-oligosaccharide glucosidase (MOGS), also known as endoplasmic reticulum (ER) glucosidase I, manifested a severe hypogammaglobulinaemia without clinical evidence of an infectious diathesis. This paradox phenomenon is, at least in part, because the impaired N-linked glycan processing of the patients compromises their ability to support efficient replication and cellular entry of viruses. This finding unambiguously validates ER glucosidases as valuable targets for antiviral agents against a broad-spectrum of enveloped viruses.
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Details
- Title
- Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections
- Creators
- Jinhong Chang - Drexel UniversityTimothy M. Block - Drexel UniversityJu-Tao Guo - Drexel University
- Publication Details
- Antiviral therapy, v 20(3)
- Publisher
- Int Medical Press Ltd
- Number of pages
- 3
- Grant note
- R01AI104636 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01 AI113267; AI232758; R01 AI104636 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000359909600001
- Scopus ID
- 2-s2.0-84937564714
- Other Identifier
- 991019168650404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Infectious Diseases
- Pharmacology & Pharmacy
- Virology