Journal article
Virus Inhibition Activity of Effector Memory CD8+ T Cells Determines Simian Immunodeficiency Virus Load in Vaccinated Monkeys after Vaccine Breakthrough Infection
Journal of virology, v 86(10), pp 5877-5884
01 May 2012
PMID: 22419810
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The goal of an effective AIDS vaccine is to generate immunity that will prevent human immunodeficiency virus 1 (HIV-1) acquisition. Despite limited progress toward this goal, renewed optimism has followed the recent success of the RV144 vaccine trial in Thailand. However, the lack of complete protection in this trial suggests that breakthroughs, where infection occurs despite adequate vaccination, will be a reality for many vaccine candidates. We previously reported that neutralizing antibodies elicited by DNA prime-recombinant adenovirus serotype 5 (rAd5) boost vaccination with simian immunodeficiency virus strain mac239 (SIVmac239) Gag-Pol and Env provided protection against pathogenic SIVsmE660 acquisition after repeated mucosal challenge. Here, we report that SIV-specific CD8
+
T cells elicited by that vaccine lowered both peak and set-point viral loads in macaques that became infected despite vaccination. These SIV-specific CD8
+
T cells showed strong virus-inhibitory activity (VIA) and displayed an effector memory (EM) phenotype. VIA correlated with high levels of CD107a mobilization and perforin expression in SIV-specific CD8
+
T cells. Remarkably, both the frequency and the number of Gag CM9-specific public clonotypes were strongly correlated with VIA mediated by EM CD8
+
T cells. The ability to elicit such virus-specific EM CD8
+
T cells might contribute substantially to an efficacious HIV/AIDS vaccine, even after breakthrough infection.
Metrics
Details
- Title
- Virus Inhibition Activity of Effector Memory CD8+ T Cells Determines Simian Immunodeficiency Virus Load in Vaccinated Monkeys after Vaccine Breakthrough Infection
- Creators
- Takuya Yamamoto - National Institutes of HealthMatthew J. Johnson - Vaccine Research CenterDavid A. Price - Cardiff UniversityDavid I. Wolinsky - National Institutes of HealthJorge R. Almeida - National Institutes of HealthConstantinos Petrovas - National Institutes of HealthMartha Nason - National Institutes of HealthWendy W. Yeh - Harvard UniversityLing Shen - Harvard UniversityMario Roederer - National Institutes of HealthSrinivas S. Rao - Vaccine Research CenterAdrian B. McDermott - National Institutes of HealthFrancois Lefebvre - Vaccine & Gene Therapy Institute of FloridaGary J. Nabel - National Institutes of HealthElias K. Haddad - VGTI-FL, Port St. Lucie, Florida, USANorman L. Letvin - Harvard UniversityDaniel C. Douek - National Institutes of HealthRichard A. Koup - National Institutes of Health
- Publication Details
- Journal of virology, v 86(10), pp 5877-5884
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000303787100043
- Scopus ID
- 2-s2.0-84861310002
- Other Identifier
- 991020099801004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Virology