Journal article
Viruses and the versatile macrophage
British medical bulletin, v 41(1), pp 15-21
1985
PMID: 3882185
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mononuclear phagocytes, including circulating monocytes and tissue macrophages, play a central role in resistance to viruses. This resitance can be expressed both non-specifically, and specifically in indiction, regulation and amplification of humoral and cell mediated immune responses to viruses. These lead to the extrinsic effect of macrophages on other virus-infected cells or free virus, and the intrinsic effect on viruses within macrophages. While these interactions usually appear to be protective, immunopathologic consequences as well as macrophage dysfunctions have also been noted. The outcome of any given interaction (viral elimination, peristance, latency or transformation) varies markedly with the type of macrophage. The molecular mechanisms involved in these very diverse macrophage-virus interactions are currently under study.
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Details
- Title
- Viruses and the versatile macrophage
- Creators
- Pages S Morahan - Drexel University, Medical College of Pennsylvania (1970-1993)Janice R Connor - Drexel University, Medical College of Pennsylvania (1970-1993)Kathryn R Leary - Drexel University, Medical College of Pennsylvania (1970-1993)
- Publication Details
- British medical bulletin, v 41(1), pp 15-21
- Publisher
- Oxford University Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1985ABE5000004
- Scopus ID
- 2-s2.0-0021943981
- Other Identifier
- 991019184198204721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology