Journal article
Visible Light Sensitized Inactivation of MS-2 Bacteriophage by a Cationic Amine-Functionalized C-60 Derivative
Environmental science & technology, v 44(17), pp 6685-6691
01 Sep 2010
PMID: 20687548
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recently, we reported the successful synthesis of various hexakis C-60 derivatives (i.e., C-60 with six functional groups containing NH3+-, CO2H-, or OH-terminals) with enhanced stability in water for aqueous phase application (Lee et al., Environ. Sci. Technol. 2009, 43, pp 6604-6610). Among these newly synthesized C-60 derivatives, the cationic hexakis C-60 derivative with amine functionality, C601CR216(R= CO2(CH2)(2)NH(3+)CF3CO2-1, was found to exhibit remarkable efficiency to inactivate Escherichia coliand MS-2 bacteriophage under UVA irradiation. Herein, we report that this amine-functionalized C-60 derivative is also photoactive in response to visible light from both commercial fluorescence lamps and sunlight. Efficient production of '02, facile reaction of 102 with proteins in MS-2 phage capsid and electrostatic attraction between positively charged C-60 derivative and negatively charged MS-2 phage collectively contributed to high efficiency of MS-2 phage inactivation in this photocatalytic disinfection system. The rate of 102 production was evaluated using a probe compound, furfuryl alcohol, and 102 CT (the product of '02 concentration and exposure time) required to achieve a target level of virus inactivation was quantitatively analyzed. The unique visible-light sensitized virucidal property makes this C-60 derivative highly desirable for the development of sustainable disinfection strategies that do not require continuous chemical addition nor an external energy source other than ambient light.
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Details
- Title
- Visible Light Sensitized Inactivation of MS-2 Bacteriophage by a Cationic Amine-Functionalized C-60 Derivative
- Creators
- Min Cho - Georgia Institute of TechnologyJaesang Lee - Rice UniversityYuri Mackeyev - Rice UniversityLon J. Wilson - Rice UniversityPedro J. J. Alvarez - Rice UniversityJoseph B. Hughes - Georgia Institute of TechnologyJae-Hong Kim
- Publication Details
- Environmental science & technology, v 44(17), pp 6685-6691
- Publisher
- Amer Chemical Soc
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Civil, Architectural, and Environmental Engineering
- Web of Science ID
- WOS:000281225800025
- Scopus ID
- 2-s2.0-77956149943
- Other Identifier
- 991021931770004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Environmental
- Environmental Sciences