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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment
Applied neuropsychology. Adult, v 23(1), pp 43-52
2016
PMID: 26397732
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Clock Drawing Test performance was examined alongside other neuropsychological tests in mild cognitive impairment (MCI). We tested the hypothesis that clock-drawing errors are related to executive impairment. The current research examined 86 patients with MCI for whom, in prior research, cluster analysis was used to sort patients into dysexecutive (dMCI, n = 22), amnestic (aMCI, n = 13), and multidomain (mMCI, n = 51) subtypes. First, principal components analysis (PCA) and linear regression examined relations between clock-drawing errors and neuropsychological test performance independent of MCI subtype. Second, between-group differences were assessed with analysis of variance (ANOVA) where MCI subgroups were compared to normal controls (NC). PCA yielded a 3-group solution. Contrary to expectations, clock-drawing errors loaded with lower performance on naming/lexical retrieval, rather than with executive tests. Regression analyses found increasing clock-drawing errors to command were associated with worse performance only on naming/lexical retrieval tests. ANOVAs revealed no differences in clock-drawing errors between dMCI versus mMCI or aMCI versus NCs. Both the dMCI and mMCI groups generated more clock-drawing errors than the aMCI and NC groups in the command condition. In MCI, language-related skills contribute to clock-drawing impairment.
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Details
- Title
- Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment
- Creators
- Samrah Ahmed - John Radcliffe HospitalLaura Brennan - Drexel UniversityJoel Eppig - Drexel UniversityCatherine C. Price - University of Florida HealthMelissa Lamar - University of Illinois at ChicagoLisa Delano-Wood - VA San Diego Healthcare SystemKatherine J. Bangen - University of California, San DiegoEmily C. Edmonds - University of California, San DiegoLindsey Clark - Wisconsin Alzheimer's Institute, Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine & Public HealthDaniel A. Nation - University of Southern CaliforniaAmy Jak - VA San Diego Healthcare SystemRhoda Au - Framingham Heart StudyRodney Swenson - University of North DakotaMark W. Bondi - VA San Diego Healthcare SystemDavid J. Libon - Drexel University
- Publication Details
- Applied neuropsychology. Adult, v 23(1), pp 43-52
- Publisher
- Routledge; ABINGDON
- Number of pages
- 10
- Grant note
- SA is supported by the National Institute for Health Research Biomedical Research Centre, Oxford, UK.
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000796731600006
- Scopus ID
- 2-s2.0-84976359875
- Other Identifier
- 991021901314904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Psychology