Journal article
Vitamin D deficiency and degree of coronary artery luminal stenosis in women undergoing coronary angiography: a prospective observational study
American journal of cardiovascular disease, v 8(2), pp 14-18
01 Jan 2018
PMID: 29755836
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background and Aims: Low serum 25-OH D levels are associated with increased cardiovascular morbidity and mortality. Recent studies have linked 25-OH D deficiency with the presence of CAD. Women, especially post-menopausal, tend to suffer from accelerated atherosclerosis, along with vitamin D deficiency. In the present study we sought to investigate whether there is a direct association of coronary artery luminal stenosis with 25-OH D deficiency in women. Patients and methods: We enrolled women aged >40 who were scheduled to undergo elective coronary angiography between 3/2011 and 10/2016 in a prospective observational study. Results: We included a total of 105 women. Patients had hypertension (73%), hyperlipidemia (54%), diabetes (29%), smoking (31%), family history of CAD (62%), and known CAD (21%). Median 25-OH D levels were 15.8 ng/mL (range, 3.9-79). Patients had left-anterior descending (31%), left circumflex (22%), and right coronary artery disease (26%); 27% had 2-vessel and 11% had 3-vessel disease. There was a significant inverse correlation between 25-OH D levels and the degree of maximum luminal stenosis. The burden of CAD increased across categories of worsening 25-OH D deficiency. Conclusions: Vitamin D deficiency is associated with the degree of luminal stenosis and burden of CAD in women undergoing coronary angiography. Future studies should investigate if the repletion of 25-OH D impacts the progression of CAD and cardiovascular mortality.
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Details
- Title
- Vitamin D deficiency and degree of coronary artery luminal stenosis in women undergoing coronary angiography: a prospective observational study
- Creators
- Chris Morgan - Allegheny Health NetworkAndreas Kyvernitakis - Allegheny Health NetworkRoy Cho - Allegheny Health NetworkOrestis Pappas - Allegheny Health NetworkKarthikeyan Ranganathan - Allegheny Health NetworkMichael R Fischer - Allegheny Health NetworkVenkatraman Srinivasan - Allegheny Health Network
- Publication Details
- American journal of cardiovascular disease, v 8(2), pp 14-18
- Publisher
- e-Century Publishing Corporation
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000431600300001
- Other Identifier
- 991021962193004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems