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Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis
Journal article   Open access   Peer reviewed

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P Sexauer, Anas Hadeh, Pamela A Ohman-Strickland, Robert L Zanni, Laurie Varlotta, Douglas Holsclaw, Stanley Fiel, Gavin R Graff, Arthur Atlas, Dorothy Bisberg, …
Journal of cystic fibrosis, v 14(4), pp 497-506
Jul 2015
DOI: https://doi.org/10.1016/j.jcf.2014.12.006
PMID: 25577127
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jcf.2014.12.006View
Published, Version of Record (VoR)Open Access (Publisher-Specific),  Open

Abstract

Adolescent Adult Child Cystic Fibrosis - blood Cystic Fibrosis - complications Cystic Fibrosis - physiopathology Female Forced Expiratory Volume - physiology Humans Male Retrospective Studies Vital Capacity - physiology Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - physiopathology Young Adult
Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

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40 citations in Web of Science
45 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Respiratory System
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